Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process
نویسندگان
چکیده
منابع مشابه
Use of Extrusion–Spheronization to Develop Controlled-Release Dosage Forms for Diltiazem Hydrochloride
*To whom all correspondence should be addressed. uring the past few decades, various types of oral controlled-release (CR) formulations have been developed to improve the clinical efficacy of drugs having short half lives as well as to increase patient compliance (1, 2). These formulations are designed to deliver drugs at a predetermined rate over a wide range of conditions and durations of the...
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Rajesh Gandhi, PhD, is a senior research scientist in Ranbaxy Research Laboratories (Gurgaon, India), Yasvanth Ashokraj is a doctoral student, Chaman Lal Kaul, PhD, is the director of the National Institute of Pharmaceutical Education and Research (NIPER), and Ramesh Panchagnula, PhD, is a professor and head of the Department of Pharmaceutics, NIPER, Sector 67, S.A.S. Nagar (Punjab) 160062 Indi...
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Formulation, Fill & Finish 2003 10 he technologies behind oral drug delivery have emerged from the mainstream pharmaceutical industry and have become influential forces in their own right, as evidenced by the burgeoning “drug delivery companies” that are at the forefront of innovation and hold their own niche market. Drug delivery companies and their pharmaceutical industry partners are poised ...
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Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems (e.g. pellets, granules) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastrointestinal tract. There are different pelletization and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion Spheronization ...
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In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Investigation
سال: 2010
ISSN: 2093-5552
DOI: 10.4333/kps.2010.40.s.103